Markos Leggas: search on Z-Library

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1

Intensive anti-inflammatory therapy with dexamethasone in patients with non-small cell lung cancer: effect on chemotherapy toxicity and efficacy

Markos Leggas, Kuei-Ling Kuo, Francisco Robert, Gretchen Cloud, Mollie deShazo, Ruiwen Zhang, Mao Li, Hui Wang, Steve Davidson, John Rinehart

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 456 KB

english, 2009

2

Reducing signs of aging and increasing lifespan by drug synergy

Huang, Xinhe, Liu, Jun, Withers, Bradley R., Samide, Aaron J., Leggas, Markos, Dickson, Robert C.

Journal:

Year:

2013

Language:

english

File:

PDF, 619 KB

english, 2013

3

Saquayamycins G–K, Cytotoxic Angucyclines from Streptomyces sp. Including Two Analogues Bearing the Aminosugar Rednose

Shaaban, Khaled A., Ahmed, Tamer A., Leggas, Markos, Rohr, Jürgen

Journal:

Journal of Natural Products

Year:

2012

Language:

english

File:

PDF, 1.37 MB

english, 2012

4

Interactions between Hepatic Mrp4 and Sult2a as Revealed by the Constitutive Androstane Receptor and Mrp4 Knockout Mice

Assem, Mahfoud, Schuetz, Erin G., Leggas, Markos, Sun, Daxi, Yasuda, Kazuto, Reid, Glen, Zelcer, Noam, Adachi, Masashi, Strom, Stephen, Evans, Ronald M., Moore, David D., Borst, Piet, Schuetz, John D.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 855 KB

english, 2004

5

Nanotemplate-Engineered Nanoparticles Containing Gadolinium for Magnetic Resonance Imaging of Tumors

Zhu, Donghua, Lu, Xiuling, Hardy, Peter A., Leggas, Markos, Jay, Michael

Journal:

Investigative Radiology

Year:

2008

Language:

english

File:

PDF, 972 KB

english, 2008

6

Development of Idarubicin and Doxorubicin Solid Lipid Nanoparticles to Overcome Pgp-Mediated Multiple Drug Resistance in Leukemia

Ma, Ping, Dong, Xiaowei, Swadley, Courtney L., Gupte, Anshul, Leggas, Markos, Ledebur, Harry C., Mumper, Russell J.

Journal:

Journal of Biomedical Nanotechnology

Year:

2009

Language:

english

File:

PDF, 1.38 MB

english, 2009

7

Expression of the Multi-Drug Resistance Proteins and the Pregnane X Receptor in Treated and Untreated Retinoblastoma

Wilson, Matthew W., Fraga, Charles H., Rodriguez-Galindo, Carlos, Hagedorn, Nikolas, Leggas, Markos L., Stewart, Clinton

Journal:

Current Eye Research

Year:

2009

Language:

english

File:

PDF, 6.12 MB

english, 2009

8

Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition

Ahmed, Tamer A., Hayslip, John, Leggas, Markos

Journal:

Leukemia Research

Year:

2014

Language:

english

File:

PDF, 2.24 MB

english, 2014

9

Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors

Tang, Fei, Tsakalozou, Eleftheria, Arnold, Susanne M., Ng, Chee M., Leggas, Markos

Journal:

Investigational New Drugs

Year:

2019

Language:

english

File:

PDF, 830 KB

english, 2019

10

Microbore HPLC method with online microdialysis for measurement of topotecan lactone and carboxylate in murine CSF

Markos Leggas, Yanli Zhuang, Jonathan Welden, Zack Self, Christopher M. Waters, Clinton F. Stewart

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 273 KB

english, 2004

11

Validated LC–MS/MS method for simultaneous determination of SIM and its acid form in human plasma and cell lysate: Pharmacokinetic application

Tamer A. Ahmed, Jamie Horn, John Hayslip, Markos Leggas

Journal:

Journal of Pharmaceutical Analysis

Year:

2012

Language:

english

File:

PDF, 611 KB

english, 2012

12

Pyramidamycins A-D and 3-hydroxyquinoline-2-carboxamide; cytotoxic benzamides from Streptomyces sp. DGC1

Shaaban, Khaled A, Shepherd, Micah D, Ahmed, Tamer A, Nybo, S Eric, Leggas, Markos, Rohr, Jürgen

Journal:

The Journal of Antibiotics

Year:

2012

Language:

english

File:

PDF, 598 KB

english, 2012

13

Pharmacokinetic Modeling to Assess Factors Affecting the Oral Bioavailability of the Lactone and Carboxylate Forms of the Lipophilic Camptothecin Analogue AR-67 in Rats

Eyob D. Adane, Zhiwei Liu, Tian-Xiang Xiang, Bradley D. Anderson, Markos Leggas

Journal:

Pharmaceutical Research

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

14

Novel Drug Treatments for Ewing Sarcoma

Hayden, Reiya, Leggas, Markos

Journal:

Current Molecular Biology Reports

Year:

2019

Language:

english

File:

PDF, 1005 KB

english, 2019

15

Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate)

Ceckova, Martina, Reznicek, Josef, Deutsch, Birgit, Fromm, Martin F., Staud, Frantisek, Leggas, Markos

Journal:

Year:

2018

Language:

english

File:

PDF, 2.42 MB

english, 2018

16

Sunitinib Malate for the Treatment of Metastatic Renal Cell Carcinoma and Gastrointestinal Stromal Tumors

Val R. Adams, Markos Leggas

Journal:

Clinical Therapeutics

Year:

2007

Language:

english

File:

PDF, 1.40 MB

english, 2007

17

The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination

Wang, Yuhuan, Liu, Xiaoxi, Pijut, Sonja S., Li, Jianing, Horn, Jamie, Bradford, Emily M., Leggas, Markos, Barrett, Terrence A., Graf, Gregory A.

Journal:

The Journal of Lipid Research

Year:

2015

Language:

english

File:

PDF, 1.06 MB

english, 2015

18

Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents

Penthala, Narsimha Reddy, Sonar, Vijayakumar N., Horn, Jamie, Leggas, Markos, Yadlapalli, Jai Shankar K. B., Crooks, Peter A.

Journal:

Year:

2013

Language:

english

File:

PDF, 393 KB

english, 2013

19

Pharmacokinetics of high-dose simvastatin in refractory and relapsed chronic lymphocytic leukemia patients

Ahmed, Tamer A., Hayslip, John, Leggas, Markos

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2013

Language:

english

File:

PDF, 233 KB

english, 2013

20

Enzymatic Methylation and Structure-Activity-Relationship Studies on Polycarcin V, a Gilvocarcin-Type Antitumor Agent

Chen, Jhong-Min, Shepherd, Micah D., Horn, Jamie, Leggas, Markos, Rohr, Jürgen

Journal:

Year:

2014

Language:

english

File:

PDF, 697 KB

english, 2014

21

Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery

Taich, Paula, Requejo, Flavio, Asprea, Marcelo, Sgroi, Mariana, Gobin, Pierre, Abramson, David H., Chantada, Guillermo, Schaiquevich, Paula, Leggas, Markos

Journal:

Year:

2016

Language:

english

File:

PDF, 318 KB

english, 2016

22

Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: Lessons learned of the EPR effect and image-guided drug delivery

Hollis, Christin P., Weiss, Heidi L., Leggas, Markos, Evers, B. Mark, Gemeinhart, Richard A., Li, Tonglei

Journal:

Journal of Controlled Release

Year:

2013

Language:

english

File:

PDF, 4.32 MB

english, 2013

23

Drug Synergy Drives Conserved Pathways to Increase Fission Yeast Lifespan

Huang, Xinhe, Leggas, Markos, Dickson, Robert C., Mata, Juan

Journal:

Year:

2015

Language:

english

File:

PDF, 2.43 MB

english, 2015

24

Pharmacokinetic Modeling of the Blood‐Stable Camptothecin Analogue AR‐67 in Two Different Formulations

Liu, Xiaoxi, Adane, Eyob, Tang, Fei, Leggas, Markos

Journal:

Biopharmaceutics & Drug Disposition

Year:

2019

Language:

english

File:

PDF, 780 KB

english, 2019

25

GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine

Lee, Na-Ra, Zheng, Guangrong, Leggas, Markos, Janganati, Venumadhav, Nickell, Justin R., Crooks, Peter A., Bardo, Michael T., Dwoskin, Linda P.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2019

Language:

english

File:

PDF, 2.71 MB

english, 2019

26

Development of Mithramycin Analogues with Increased Selectivity towards ETS Transcription Factor Expressing Cancers

Mitra, Prithiba, Eckenrode, Joseph M., Mandal, Abhisek, Jha, Amit K., Salem, Shaimaa M., Leggas, Markos, Rohr, Jurgen

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 642 KB

english, 2018

27

Validation of a HPLC/MS Method for Simultaneous Quantification of Clonidine, Morphine and its Metabolites in Human Plasma

Tang, Fei, Bada, Henrietta, Ng, Chee M., Leggas, Markos

Journal:

Biomedical Chromatography

Year:

2019

Language:

english

File:

PDF, 955 KB

english, 2019

28

Stable RNA nanoparticles as potential new generation drugs for cancer therapy

Shu, Yi, Pi, Fengmei, Sharma, Ashwani, Rajabi, Mehdi, Haque, Farzin, Shu, Dan, Leggas, Markos, Evers, B. Mark, Guo, Peixuan

Journal:

Advanced Drug Delivery Reviews

Year:

2014

Language:

english

File:

PDF, 2.76 MB

english, 2014

29

Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations

Krauss, Markus, Tappe, Kai, Schuppert, Andreas, Kuepfer, Lars, Goerlitz, Linus, Leggas, Markos

Journal:

Year:

2015

Language:

english

File:

PDF, 1.89 MB

english, 2015

30

Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

Sun, Hao, Piotrowski, David W., Orr, Suvi T. M., Warmus, Joseph S., Wolford, Angela C., Coffey, Steven B., Futatsugi, Kentaro, Zhang, Yinsheng, Vaz, Alfin D. N., Leggas, Markos

Journal:

Year:

2018

Language:

english

File:

PDF, 2.21 MB

english, 2018

31

Phase II Trial of Carfilzomib Plus Irinotecan in Patients With Small-cell Lung Cancer Who Have Progressed on Prior Platinum-based Chemotherapy

Arnold, Susanne M., Chansky, Kari, Baggstrom, Maria Q., Thompson, Michael A., Sanborn, Rachel E., Villano, John L., Waqar, Saiama N., Hamm, John, Leggas, Markos, Willis, Maurice, Rosales, Joseph, Crow

Journal:

Clinical Lung Cancer

Year:

2020

File:

PDF, 962 KB

2020

32

Population pharmacokinetic modelling of rupatadine solution in 6–11 year olds and optimisation of the experimental design in younger children

Santamaría, Eva, Estévez, Javier Alejandro, Riba, Jordi, Izquierdo, Iñaki, Valle, Marta, Leggas, Markos

Journal:

Year:

2017

Language:

english

File:

PDF, 3.58 MB

english, 2017

33

Localization and Functional Characterization of the Rat Oatp4c1 Transporter in an In Vitro Cell System and Rat Tissues

Kuo, Kuei-Ling, Zhu, Haining, McNamara, Patrick J., Leggas, Markos, Butterworth, Michael

Journal:

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

34

Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp

Zhao, Minzhi, Lei, Chunni, Yang, Yadong, Bu, Xiangli, Ma, Huailei, Gong, He, Liu, Juan, Fang, Xiangdong, Hu, Zhiyuan, Fang, Qiaojun, Leggas, Markos

Journal:

Year:

2015

Language:

english

File:

PDF, 2.38 MB

english, 2015

35

Factors Affecting theIn VivoLactone Stability and Systemic Clearance of theLipophilicCamptothecin Analogue AR-67

Eyob D. Adane, Zhiwei Liu, Tian-Xiang Xiang, Bradley D. Anderson, Markos Leggas

Journal:

Pharmaceutical Research

Year:

2010

Language:

english

File:

PDF, 314 KB

english, 2010

36

Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants II: Role of Plasma Esterases in Drug Release

Xiuling Lu, Melissa D. Howard, Dominique R. Talbert, John J. Rinehart, Philip M. Potter, Michael Jay, Markos Leggas

Journal:

The AAPS Journal

Year:

2009

Language:

english

File:

PDF, 96 KB

english, 2009

37

High Payload Dual Therapeutic-Imaging Nanocarriers for Triggered Tumor Delivery

Jin-Ki Kim, Hong Yuan, Jingxin Nie, Yu-Tsai Yang, Markos Leggas, Philip M. Potter, John Rinehart, Michael Jay, Xiuling Lu

Journal:

Year:

2012

Language:

english

File:

PDF, 867 KB

english, 2012

38

Phase 1b trial of proteasome inhibitor carfilzomib with irinotecan in lung cancer and other irinotecan-sensitive malignancies that have progressed on prior therapy (Onyx IST reference number: CAR-IST-553)

Arnold, Susanne M., Chansky, Kari, Leggas, Markos, Thompson, Michael A., Villano, John L., Hamm, John, Sanborn, Rachel E., Weiss, Glen J., Chatta, Gurkamal, Baggstrom, Maria Q.

Journal:

Investigational New Drugs

Year:

2017

Language:

english

File:

PDF, 356 KB

english, 2017

39

Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans

Tsakalozou, Eleftheria, Adane, Eyob D., Liang, Yali, Arnold, Susanne M., Leggas, Markos

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2014

Language:

english

File:

PDF, 762 KB

english, 2014

40

Pharmacokinetic modeling of gentamicin in treatment of infective endocarditis: Model development and validation of existing models

Gomes, Anna, van der Wijk, Lars, Proost, Johannes H., Sinha, Bhanu, Touw, Daan J., Leggas, Markos

Journal:

Year:

2017

Language:

english

File:

PDF, 1.66 MB

english, 2017

41

Validation of an HPLC method for analysis of DB-67 and its water soluble prodrug in mouse plasma

Jamie Horn, Sherri L. Jordan, Lin Song, Michael J. Roberts, Bradley D. Anderson, Markos Leggas

Journal:

Journal of Chromatography B

Year:

2006

Language:

english

File:

PDF, 295 KB

english, 2006

42

Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants: Optimization andIn VitroCharacterization

Xiuling Lu, Melissa D. Howard, Marta Mazik, Joshua Eldridge, John J. Rinehart, Michael Jay, Markos Leggas

Journal:

The AAPS Journal

Year:

2008

Language:

english

File:

PDF, 251 KB

english, 2008

43

Immunohistochemical Detection of Multidrug-Resistant Protein Expression in Retinoblastoma Treated by Primary Enucleation

Wilson, Matthew W., Fraga, Charles H., Fuller, Christine E., Rodriguez-Galindo, Carlos, Mancini, John, Hagedorn, Nikolaus, Leggas, Markos L., Stewart, Clinton F.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2006

Language:

english

File:

PDF, 1.14 MB

english, 2006

44

Bioanalytical method for quantitative determination of mithramycin analogues in mouse plasma by HPLC‐QTOF

Eckenrode, Joseph M., Mitra, Prithiba, Rohr, Jürgen, Leggas, Markos

Journal:

Biomedical Chromatography

Year:

2019

Language:

english

File:

PDF, 1004 KB

english, 2019

45

Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition

Abigail Daily, Noel R. Monks, Markos Leggas, Jeffrey A. Moscow

Journal:

Year:

2010

Language:

english

File:

PDF, 1.05 MB

english, 2010

46

Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691

Shaaban, Khaled A., Elshahawi, Sherif I., Wang, Xiachang, Horn, Jamie, Kharel, Madan K., Leggas, Markos, Thorson, Jon S.

Journal:

Journal of Natural Products

Year:

2015

Language:

english

File:

PDF, 941 KB

english, 2015

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